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Here are some significant events in Philippine history that occurred on December 21:

1. 1581:
The Manila Cathedral was established by a decree from Pope Gregory XIII under the title of the Immaculate Conception.

2. 1614:
Dom Justo Ukon Takayama, a Japanese Christian daimyō and missionary, arrived in the Philippines after being exiled from Japan due to his Christian faith.

3. 1898:
U.S. President William McKinley issued the “Benevolent Assimilation” Proclamation, outlining the American policy of governance in the Philippines, leading to increased tensions and the eventual Philippine-American War.

4. 1935:
Philippine President Manuel L. Quezon signed Commonwealth Act No. 1, also known as the National Defense Act of 1935, which laid the foundation for the modern Armed Forces of the Philippines.